Aunt Lizzy wants to sit near Aunt Fran and Bob wants to chat with Joe and you need to make sure everyone gets a chance to be near the people they want to sit with. NOT an easy task, but this is how you will make your guests happy and comfortable.
1 Go through your list and see who the buddies are outside of family lines.
2. If you invite kids you can put kids at a table by themselves near a table of parents nearby if they are old enough (over 5).
3 If anyone is disabled or Ill it will be best to put their table near the door and not across the room in a corner.
4 Put your youngest and biggest partyers near the bandstand and your guests more sensitive to music in the far end of the room.
5 Make sure everything is symmetrical.
6. Food service, Buffets...Don't put a buffet with stations on opposite ends of a room with tables in the middle and make people carry plates across the floor.